Virtual screening is the most critical process in drug discovery, and it relies on machine learning to facilitate the screening process. It enables the discovery of molecules that bind to a specific protein to form a drug. Despite its benefits, virtual screening generates enormous data and suffers from drawbacks such as high dimensions and imbalance. This paper tackles data imbalance and aims to improve virtual screening accuracy, especially for a minority dataset. For a dataset identified without considering the data’s imbalanced (...) nature, most classification methods tend to have high predictive accuracy for the majority category. However, the accuracy was significantly poor for the minority category. The paper proposes a K-mean algorithm coupled with Synthetic Minority Oversampling Technique to overcome the problem of imbalanced datasets. The proposed algorithm is named as KSMOTE. Using KSMOTE, minority data can be identified at high accuracy and can be detected at high precision. A large set of experiments were implemented on Apache Spark using numeric PaDEL and fingerprint descriptors. The proposed solution was compared to both no-sampling method and SMOTE on the same datasets. Experimental results showed that the proposed solution outperformed other methods. (shrink)

The necessity of having effective and socially sound networks is trivial. It is clear that information technology is now a necessary tool that has well understood advantages. The same technology carries negative side-effects. It is our social and ethical duty to examine the possibly negative side effects of IT, especially as IT becomes prevalent in a conservative society such as Kuwait. In our research Kuwait forms a case study as we try to understand what ethical theories underlie the attitude toward (...) one problematic aspect of IT, online pornography, in Muslim/Arab societies. In this paper we review several ethical theories and then present the results of experimental research aimed at determining the concepts that underlie the Kuwaiti response to pornography online. (shrink)

BackgroundAccess to research volunteers may be hampered by low numbers of cases and few eligible participants for rare diseases in clinical settings.MethodsWe recruited volunteers and obtained informed consent by mail from narcolepsy cases in a case-control study, and here in we report feasibility, response rate, timeliness and cost. We invited index cases into the study by mail through their care-giving physicians then mailed study information and consent forms to cases that indicated interest in the study.ResultsOf the 33 index cases invited, (...) 15 expressed interest in the study, and of those, 14 returned their signed informed consents by mail. The median number of days from invitation to consent return was 39, interquartile range = 45, and the cost per consent obtained from the recruited subjects was $ 23.61.ConclusionIn this setting, postal recruitment for biomedical research on rare conditions is feasible and time and cost effective. (shrink)

Lean design and agile design paradigms have been proposed for designing robots; yet, none of them could strike a balance between cost-effectiveness and short duration of the design process without compromising the quality of performance. The present article identifies the key determinants of the mobile robots development process. It also identifies empirically the mobile robot design activities and strategies with the most influence on mobile robot performance. The study identified statistically the mobile robot design activities and strategies most positively correlated (...) with mobile robot performance. The results showed that 65% of typical mobile robot design activities and strategies are affiliated with the lean design paradigm, while the remaining 35% are affiliated with the agile design paradigm. In addition, it was found that 22% of the lean mobile robot design activities and strategies and 25% of the agile mobile robot design activities and strategies, significantly with 99% confidence, are among the design activities and strategies most positively correlated with improving mobile robot performance. A hybrid lean-agile design paradigm is thus proposed. (shrink)

Parkinson's Disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking. Doctors do not know what causes it and finds difficulty in early diagnosing the presence of Parkinson’s disease. An artificial neural network system with back propagation algorithm is presented in this paper for helping doctors in identifying (...) PD. Previous research with regards to predict the presence of the PD has shown accuracy rates up to 93% [1]; however, accuracy of prediction for small classes is reduced. The proposed design of the neural network system causes a significant increase of robustness. It is also has shown that networks recognition rates reached 100%. (shrink)

We give a polynomial time controlled version of a theorem of M. Hall: every real number can be written as the sum of two irrational numbers whose developments into a continued fraction contain only 1, 2, 3 or 4.

This study examines the influence of the COVID-19 crisis on academic expectations among international students from north-western China. According to past studies, academic expectations are multifaceted, making it critical to test the methods employed to assess this fundamental trait. The outbreak of COVID-19 has resulted in various significant changes in education, which have shifted from traditional to online or mixed formats. As a result, examining international students' academic expectations along with their interactions with adopted technologies is a topic that addresses (...) the current situation and issues. A mixed approach, comprising two different instruments, was followed to achieve this primary objective. While a survey with a questionnaire was undertaken with 551 international students, divided into two groups, ten students were interviewed during and after the lockdowns. The findings revealed that COVID-19 had a significant impact on the academic expectations of students as well as many elements such as training for employment, personal and social development, international student mobility, motivation, social pressure, and social interaction with the help of supporting technologies. In terms of gender, men outperformed women in motivation, social interaction, training for employment, and personal and social development factors. Similarly, as per the grade variable, the same higher trend was seen in postgraduates. Based on these findings, a set of recommendations was put forward. In the future, technology will be helpful in China's educational sector, such as online group collaboration, open education, managing student retention, and supervising teachers' recruitment. (shrink)

In this paper, an intelligent neural network-based controller is designed and implemented to control the speed of a permanent magnet synchronous motor. First, the exact mathematical model of PMSM is presented, and then, by designing a controller, we apply the wind turbine emulation challenges. The designed controller for the first time is implemented on a Arm Cortex-M microcontroller and tested on a laboratory PMSM. Since online learning neural network on a chip requires a strong processor, high memory, and convergence guarantee, (...) this article uses the offline method. In this method, first, for different work points, the neural network is trained by local controllers, and then, the trained network is implemented on the chip and used. Uncertainty in the parameters and the effect of load torque as challenges of control systems are applied in the proposed method, and a comparison with other methods is performed in the implementation results section. (shrink)

Lima gagasan yang dapat mengubah Indonesia itu tentu Pancasila. Sebagaimana ditulis Jakob Oetama dalam kata pengantar buku Profesor Sastrapratedja, sudah sangat mendesak untuk mengaktualisasikan kembali Pancasila. Pancasila sudah lama berada dalam bahaya, bukan karena masih ada kekuatan politik yang mempersoalkannya, melainkan karena dukungan terhadap Pancasila cenderung menguapkan maknanya. Di masa Demokrasi Terpimpin Pancasila semakin dikesampingkan oleh semboyan-semboyan lain di mana yang paling tragis adalah NASAKOM. Di masa Orde Baru Pancasila dinyatakan sakti dan sesudahnya jutaan saudara dan saudari sebangsa dibunuh, dikucilkan, (...) dan dihancurkan eksistensinya; Pancasila menjadi payung salah satu kejahatan terbesar dalam sejarah umat manusia. Dan kemudian, melalui manipulasi, seperti dalam Pedoman Penghayatan dan Pengamalan Pancasila, Pancasila di-jawa-kan—dalam pidatonya di Pekanbaru Suharto mengatakan bahwa untuk memahami Pancasila orang perlu tahu falsafah honocaroko—dan dibonsai menjadi anjuran untuk bersikap baik-baik, bebas bertanggungjawab di bawah naungan pemerintah. Pancasila bonsai itu diindoktrinasikan melalui kursus-kursus BP7 kepada masyarakat. Maka waktu Suharto meninggalkan tahta kekuasaannya, Pancasila seakan sudah masuk kotak, orang sepertinya malu berbicara mengenai Pancasila. Panggung ideologis yang kosong segera mulai diisi oleh ideologi-ideologi picik-agamis-eksklusivis yang betul-betul mau membersihkan Indonesia dari sisa Pancasila. Maka pada 2006 AIPI (Akademi Ilmu Pengetahuan Indonesia) menyerukan kepada Presiden Susilo Bambang Yudhoyono agar Pancasila kembali dijadikan acuan akhir eksplisit segala kebijakan kenegaraan. Karena itu, pemahaman kembali tentang arti Pancasila sangat mendesak. Itulah aktualitas buku Professor Sastrapratedja. Judulnya bukan sekedar kata keren. Sastrapratedja menunjukkan bahwa Pancasila bukan sebuah dokumen sejarah saja—seperti Declaration of Independence Amerika Serikat—atau sebuah pilar di atasnya bangsa Indonesia meneruskan perjalanannya. Sastrapratedja memperlihatkan bahwa Pancasila mempunyai gigi; artinya, Pancasila merupakan petunjuk tajam tentang kebijakan mana yang boleh dan tidak boleh diambil oleh negara yang mewujudkan bangsa Indonesia. Sastrapratedja menunjukkan dengan rinci bahwa kalau kita mengaku mendasarkan kehidupan bangsa pada lima sila Pancasila maka ada konsekuensinya. Ada kebijakan yang wajib diambil dan ada kebijakan yang wajib ditolak. Kalau negara kita mengikuti petunjuk Pancasila maka negara kita akan berubah. Buku ini terdiri dari dua puluh tiga makalah yang ditulis penulis dalam lima belas tahun terakhir. Bentuk itu menguntungkan karena pembaca tidak perlu membaca 393 halaman teks ini dari permulaan sampai akhir. Daftar isi yang cukup jelas, sebuah indeks nama dan sebuah indeks analitis rinci membantu pembaca untuk menemukan persis apa yang dicarinya. Sastrapratedja tentu tidak hanya membicarakan Pancasila. Di antara sekian masalah yang dibicarakan ada, misalnya, ”etika ilmu pengetahuan“—yang menurut Sastrapratedja memuat lima prinsip: harus menghormati martabat manusia sebagai pribadi, berpegang pada prinsip ”tidak merugikan,” terarah pada kesejahteraan bagi manusia dan masyarakat seluruhnya, pada pengurangan penderitaan, serta pada pemerataan hasil-hasilnya—, ”nasionalisme,“ ”jati diri manusia Indonesia,“ ”globalisasi“ dan tantangannya, pelbagai arti kata ”ideologi,“ ”etika politik,“ arti ”budaya politik,“ ”multikulturalisme,“ ”krisis modernitas“ sampai ”keamanan pangan“ sebagai tantangan etis........ Satu muatan Pancasila yang diangkat oleh Sastrapratedja adalah bahwa ”Pancasila menjadikan kehidupan masyarakat dan negara lebih manusiawi.” Mempancasilakan Indonesia berarti membuat bangsa Indonesia hidup bersama dengan lebih manusiawi. Hal itu eksplisit dituntut dalam sila kedua, tetapi memancar ke semua sila. Lebih manusiawi berarti penolakan terhadap kekerasan sebagai sarana untuk menyelesaikan masalah. Pancasila mendorong untuk mengusahakan “penghalusan perasaan” dan “transformasi keagresifan” manusia Indonesia. Ketuhanan Yang Maha Esa memanusiakan manusia dengan mengajak menghormati perbedaan, mengakui identitas semua warga dan komunitas masyarakat, dan dengan menjamin kebebasan beragama dan ”toleransi” terhadap kemajemukan. Menjunjung tinggi Pancasila membawa kewajiban untuk menjamin hak-hak asasi manusia. Demokrasi membawa ”komitmen pada kesamaan.” Usaha mewujudkan keadilan sosial berakar dalam solidaritas. Bahwa Pancasila merupakan suatu etika politik, menurut Sastrapratedja, tidak berarti bahwa Pancasila tidak menyangkut sikap etis manusia Indonesia masing-masing. Pancasila dapat menjadi etika politik apabila nilai-nilai Pancasila dihayati oleh masyarakat masing-masing. Sesuai dengan lima silanya karakter manusia Pancasilais ditandai oleh lima kemampuan: kemampuan untuk menghargai perbedaan, untuk membawa diri secara manusiawi dan santun, untuk mencintai tanah airnya, untuk bersikap demokratis, serta bersikap adil dan solider. Pendidikan Pancasila dengan demikian adalah pendidikan yang mendukung perkembangan sikap-sikap Pancasilais itu. Sesuatu yang masih dapat dimasukkan ke dalam edisi berikut buku ”Lima Gagasan…” adalah tanggapan terhadap pelbagai paham tentang Pancasila yang selama ini muncul di Indonesia. Ada sebuah koreksi kecil. Catatan Delanty, yang dikutip Sastrapratedja, yang mengatakan bahwa Ayatullah Khomeini dulu menyebarkan gagasannya lewat internet (hlm. 85) tentu keliru. Waktu Khomeini di Paris—dan sampai ia meninggal dunia—belum ada internet. (Franz Magnis-Suseno, Guru Besar Ilmu Filsafat Emeritus, Sekolah Tinggi Filsafat, Driyarakra, Jakarta ). (shrink)

In addition to the prose works that were copyrighted on the hadith method, poetry studies called Alfīyah also emerged. The main motive behind the naming of the Alfīyahs is to ensure that the information is easily memorized and remembered. For this purpose, Suyūṭī also wrote an Alfīyah named Naẓm al-Durar fī ʻilm al-asar on the method of hadith. Suyūṭī felt the need to write a new Alfīyah himself by considering Ibn al-Ṣalāḥ's ʻUlūm al-ḥadīth and al-ʻIrāqī's Alfīyah named al-Tabṣirah wa al-Tadhkirah. (...) Suyūṭī claimed that his Alfīyah is superior to al-ʻIrāqī's Alfīyah in terms of covering all subjects (Jamʻ), concise style (Ījāz) and composition (Ittisāq). When the Alfīyah is examined, it is seen that 17 subjects of hadith method, which is not included in the works of Ibn al-Ṣalāḥ and ʻIrāqī, has been added to the Alfīyah. On the other hand, it has been determined that the works of scholars such as Ibn Ḥajar were also used in Alfīyah, apart from Ibn al-Ṣalāḥ and ʻIrāqī's Alfīyahs. From this point of view, it should be noted that Alfīyah is not just a summary and poetry activity, but a work containing valuable information in terms of hadith science. In this article, after giving concise information about the Alfīyah literature, the place of Suyūṭī's Naẓm al-Durar fī ʻilm al-asar, who wrote works in almost every field of Islamic sciences, in the hadith literature has been emphasized and his work which became famous with the name Alfīyat al-Suyūṭī has been examined in terms of hadith methodology. (shrink)

Buku yang ditulis oleh Dr. A. Setyo-Wibowo (SW) dan Haryanto Cahyadi, M. Hum. (HC), dua-duanya dosen filsafat, yang satu di Jakarta, yang satu di Jayapura, ini betul-betul memperkaya pustaka tentang filsafat dalam bahasa Indonesia. Platon tetap salah satu filosof terbesar, kalau bukan filosof terbesar segala zaman. Dalam buku ini para penulis mengantar pembaca ke jantung filsafat Platon. Mereka melakukannya dengan membawa pembaca ke dalam teks-teks kunci Platon. Yang mereka angkat adalah pemikiran Platon tentang pendidikan. Pendidikan bukan salah satu (...) bidang pemikiran Platon, melainkan intinya. Seluruh filsafat Platon, seperti setiap filsafat sejati, akhirnya hanya punya satu tujuan: ia mau mencerahkan. Ya mencerahkan kita. Menunjukkan ke mana kita harus mengarahkan dan mengembangkan kita agar kita menjadi manusia yang mutu. Buku ini membuat kita betul-betul mengerti Platon, tidak hanya seperti dalam buku-buku “ringkasan sejarah filsafat”, melainkan secara mendalam. Namun buku SW dan HC ini mempunyai nilai lebih. Mereka tidak hanya membawa kita ke Platon, melainkan mengangkat aktualitas pemikirannya. Platon mau mendidik pemimpin negara. Ia tidak berfilsafat dalam udara kosong, melainkan pada zaman di mana demokrasi Athena sudah kacau balau karena disandera oleh elit-elit korup. Dalam situasi ini Platon mengembangkan konsepsinya tentang suatu pendidikan yang bisa melahirkan pemimpin negara yang baik. SW dan HC menunjukkan bahwa pemikiran Platon 2500 tahun lalu sekarang di Indonesia pun masih pantas diperhatikan. Buku ini bukan bacaan gampang. Uraiannya tidak secara esai omongan ringan, melainkan betul-betul ngilmu, memakai metode-metode analisa filosofis, mengutip dari teks-teks Platon sendiri, dengan mengacu pada pustaka para ahli Platon yang state of the art. Bahasa pun tidak menggampangkan. Untuk tetap rapat dengan teks, mereka suka memakai kata-kata kunci dalam bahasa Yunani. Ambil misalnya judul ini: "Paideia Kaum Sofis: Penciutan Aisthesis-Arete dan Dominasi 'Empeiria'". Pembaca mana langsung akan tahu apa kiranya akan dibahas. Pembaca barangkali sering harus mencari dalam daftar istilah (yang, sayang, tidak lengkap) apa arti suatu kata, misalnya logistikon atau Iliados, kemudian lupa lagi, cari lagi dst. Tetapi bagi pembaca yang bertahan ganjarannya besar. Ia akan masuk ke dalam pemikiran Platon yang asli, rinci, sangat menarik...................... Masih satu catatan tentang cita-cita manusia yang kaloskagathos, elok nan baik. Membaca uraian bagus para penulis saya terdorong untuk bertanya apakah bukan sudah waktunya cita-cita Yunani kuno yang dalam etika kontemporer sama sekali hilang itu perlu diangkat kembali. Paham manusia mutu sebagai manusia elok nan baik berhasil melepaskan etika dari moralisme sempit (searah dengan MacIntyre – After Virtue – yang mengangkat kembali paham "keutamaan" Yunani yang kuat dan utuh terhadap paham mandul-moralistik istilah "keutamaan" dalam budaya Barat). Begitu pula etika Jawa memahami kebaikan manusia yang mantap dan utuh dalam keterkaitan antara kebaikan etis dan kebaikan estetik. - Catatan kecil: Dalam indeks seharusnya tidak dimuat nama yang terdapat dalam daftar pustaka. Buku Setyo Wibowo dan Haryanto Cahyadi ini bukan hanya pandu kompeten ke jantung filsafat Platon, melainkan memberikan rangsangan-rangsangan baru untuk pemikiran filosofis. (Franz Magnis-Suseno, Program Pascasarjana, Sekolah Tinggi Filsafat Driyarkara, Jakarta). (shrink)

al-Zarkashī, an ethnic Turk, is an important hadith, fiqh and commentary scholar who lived during the Mamlūks period. He was taught by some of the leading scholars of his era, such as Alā al-Dīn Mughultay (d. 762/1360), Imād al-Dīn Ibn Kashīr (d. 774/1372) ve Jamal al-Dīn al-Asnawī (d. 772/1370), and he grew up under their mentorship. Nevertheless, his only well-known student is Birmāvī (d. 831/1428). Almost half of his works have been related to fiqh and methodology of fiqh, and he (...) has also written some important works in the field of hadith. Among these, especially al-Tadhkira, al-Nukat alā Ibn al-Salāh, al-Nukat alā al-Umda fī al-Ahkām ve al-Icāba are worthy of mention. The work named al-Tadhkira, which we built our work upon, is the first known work to have been preserved in the field. Due to his being a first in his field, he was vastly studied as to how he evaluated the narrations and what kind of procedure he followed. In this work of his, not only the criticism but also the application of the text criticism adds to the importance of the work. Then, on the basis of this work, scholars such as al-Sakhāwī and al-Aclūnī made complementary works on the same subject. Summary: It is inevitable for a person to be shaped by the society he lives in. During the time when al-Zarkashī lived, Egypt was under the rule of the Mamlūks. The history of Mamlūks is examined under two periods: 1. Bahrī or Turkish Mamlūks (745 / 1344 - 794-1391) 2. Burjī or Circassian Mamlūks (784 / 1382 - 923 / 1517) period. Our author lives in both periods. About forty years of his life was in the period of Bahrī and the rest was in the period of Burjī. In both periods, the state did not have a full political authority in the country, but this was not the case in education and training. In fact, on the contrary to the political situation, scientific activities have accelerated by the arrival of many scholars to the land of Mamlūk because of the Mongol invasions coming from the east and the Crusades from the west. The increase of scientific activity was caused not only by the coming of the scholars but also by the support given by the Mamlūk sultans. In fact, they built many new madrasas in addition to the resurrection of the old ones. In addition to madrasas during the Mamlūks period, mosque, hāngāh, ribat and zāwiya are also among the educational places.Hadith, fiqh and Tafsir scholar al-Zarkashī is originally Turkish. He was born in Cairo at 745 under the conditions mentioned above. His family learned of gold and silverworking because of their subsequent settlement to Egypt, and they made their living with this craft. A person who performs this is called Zarkash in Arabic. Muhammad ibn Bahādır, who learned and did this job, was known as al-Zarkashī. al-Zarkashī, known for his love of science since childhood, was trained hadith by Alā al-Dīn Mughultay (d. 762/1360) and Imād al-Dīn Ibn Kashīr (d. 774/1372) in Damascus, and fiqh by al-Asnawī (d. 772/1370). Among his beneficiaries are distinguished personalities such as al-Subkī (d. 756/1355), al-Azraī (d. 783/1381) and al-Bulqīnī (d. 824/1421). The most remarkable of his student is al-Birmāvī (d. 831/1428).It is known that he wrote about fifty works in hadith, tafsir, fiqh, methodology of fiqh and other fields. Especially among these works al-Burhān fī ʻUlūm al-Qur’ān, al-Tadhkira, al-Ijāba, al-Bahr al-Muhīt fî Usūl al-Fiqh ve al-Mansūr fī al-Qawāid is worth mentioning. Studies on al-Burhān and al-Bahr were carried out at the level of Master and PhD.al-Zarkashī did not hesitate to criticize any person for whom he had found his mistake. For example, even though he has a great love for him, and even because of this love, he has been given the name of al-Minhāj, the criticism of al-Nawawī is the clearest indication of the value given to science. Not just him, critics of scholars such as al-Hākim al-Naysābūrī and Ibn ʻAbd al-Barr who are recognized as authority in hadith can also be considered in this framework.The work named al-Tadhkira which we have studied in our work is of importance in that it shows the accumulation of knowledge in the field of hadith. In order to compose this work, it is necessary to have enough information in this field since the riwāyas must be criticized in terms of isnād and text. To compose his work, al-Zarkashī has benefited from about a hundred and forty works related to hadith, tafsir, al-siyar, history, tabakāt, commentary, jarh - taʻdīl, ilal and maghāzī. The use of such works is an effort to reach all sources and right information as much as possible. Some of these sources are basic hadith books such as al-Bukhārī (d. 256/870) al-Sahīh, Muslim (d. 261/875) al- Sahīh, Abū Dāʾūd (d. 275/889) al-Sunan, al-Tirmidhī (d. 279/892) al-Sunan, al-Nasā’ī (d. 303/915) al-Sunan, Ibn Mādja (d. 273/887) al-Sunan, Mālik ibn Anas (d. 179/795) al-Muwatta, Ahmad ibn Hanbal (d. 241/855) al-Musnad, al-Dārimī (d. 255/869) al-Sunan, ʻAbd al-Razzāq al-Sanʻānī (d. 211/826-27) al-Musannaf, Ibn Abī Shayba (d. 235/849) al-Musannaf, Ibn Rāhwayh (d. 238/853) al-Musnad, al- Bazzār (d. 292/905) al-Musnad, Abu Yaʻlā el-Mawsilī (d. 307/919) al-Musnad, Ibn Hibbān (d. 354/965) al-Sahīh, al-Tabarānī (d. 360/971) al-Muʻjam al-Awsat and al-Muʻjam al-Kabīr, al-Hākim al-Naysābūrī (d. 405/1014) al-Mustadrak.al-Zarkashī divided the riwāyas he had studied into eight subjects. These are judgments, wisdom, zuhd, medicine, virtue, prayer, story, words and riwāyas circulating in language. He shares the information he obtains from sources about him after mentioning the riwāyas he will examine. For example, it is mentioned that there is not a hadith which is transmitted as a hadith, it is a word of a sahāba, tābiun or a person. He transferred on the riwāyas the sources mentioned in the sources, but also stated that he did not participate in some information as the place came.The author has evaluated the narrators of the riwāyas from the point of jarh and taʻdīl. He did not only evaluate riwāyas in terms of isnād, but also text criticism. This activity is a distinctive feature of his work.al-Zarkashī gave information about the misrepresentation of the name of the narrators. He also explained the strange words that are difficult to understand in the text. It is a manifestation of his knowledge in the fiqh area that some of the riwāyas that are considered weak are expressed in some sects. The author described some errors about the riwāyas. For example, he stated that a riwāya that is said to be marfūʻ is a mavkūf. al-Zarkashī also included verses, hadiths and poems about the riwāya that he had studied while writing his work or he defended it by saying that it is not the case of a riwāya that is said to be fictitious.Perhaps it is the weakest point of al-Zarkashī’s work not to give any information about some riwāya, only to mention their isnāds. He also found some riwāyas that did not have a reliable isnāds and stated that their meanings are correct. This knowledge has become an enlightening characteristic for later generations.This work has a great significance in showing that the majority of the riwāyas that spread among the people are not hadiths. As a matter of fact, 73% of the riwāyas examined in the work are weak or irrelevant riwāyas. This work of al-Zarkashī is unique. The existence of such a work has not been determined before him. This work constituted the basis of the works written by scholars such as al-Sakhāwī and al-Aclūnī in the same subject after him. (shrink)

Sensible people advise one not to expend one's strength on polemics. And sensible people are right, of course. But look at the history of social thought: there is no peace beneath the olives, and without the flames of social thought, even the pure light of science begins to flicker.

The Journal of Mind and Behavior, Winter 2003, Volume 24, Number 1, Pages 91–118, ISSN 0271–0137 This paper focuses on a logical systems flow-down of a set of consciousness requirements, which together with biological quantification of human brain anatomy sets limits on the neurological network in the cerebrum in order to produce the mind. It employs data to validate inferences, or when data do not exist, proposes methods for acquiring valid evidence. Many of these systems requirements will be imposed after (...) some fundamental assumptions are made. These assumptions are not new to theories on consciousness. However, their application as fundamentals may actually represent a new approach. Concurrent with these fundamentals, explicit periods of awareness while conscious are employed. Justification for their use is found in a theoretical process described as cerebral fusion. Additionally, storage of memory elements is postulated within local glia sites, proximal to synaptic nodes, and conductive transport through the astrocytes responsible for recall of data. The model permits variations in neural–glial interface physics and allows forecasts of mind/brain dysfunctions to be inferred. One key result from the model is hypothesized and expanded upon, and may have impact in certain types of dementia, such as Alzheimer’s disease. (shrink)

Genetic and environmental factors leading to Alzheimer's disease (AD) converge in a pathogenic pathway that leads to the accumulation of mis‐folded amyloid peptide (Aβ) in the brain. Removal of Aβ from the brain has thus been the focus of academic and industrial research in the last decade. The concept of immunization therapy could be proven in animal models mimicking amyloid pathology but a multicenter clinical trial in which AD patients were vaccinated with aggregated Aβ has resulted in somewhat unanticipated and (...) partially conflicting results. The occurrence of meningoencephalitis in 6% of vaccinated individuals forced the discontinuation of the clinical study, preventing the generation of sufficient data for an unequivocal statement about the effectiveness of such a therapy approach. This study, however, clearly showed that vaccination induced the production of antibodies against Aβ in some immunized patients. Moreover, circulating anti‐Aβ antibodies are found in healthy humans suggesting a protective role of such physiological antibodies. Nonetheless, the physiological role of the immune system in preventing AD is not fully understood. This article summarizes crucial animal and clinical data underscoring the potential of the immune system for AD treatment. BioEssays 29:927–932, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Objectives: The introduction of the living donation in organ transplantation introduces important new psychological conflicts and ethical questions in the transplantation process. Operation related risks, as well as dependencies in the family structure, generate considerable pressure on potential donors. The aim of the study was to reconstruct the determinants of willingness to donate before transplantation.Methods: Evaluation of 20 taped and transcribed interviews oriented to current approaches in qualitative interview research. The approach used is based on grounded theory, qualitative content analysis, (...) and the concept of the ideal type.Results: Before surgery, “openly motivated” donors push for an operation, leaving no room for ambivalence in the evaluation process. They idealise the relationship with the recipient, and link their donation with the individual—partly in subconscious expectations and wishes. In contrast, “openly ambivalent” donors formulate their anxieties and express arguments against donation.Conclusions: Statements that claim ambivalence towards donation or utterance of arguments against donation indicate earlier coercion. Before transplantation, potential donors should have the opportunity to discuss their emotional situation to help their decision making process. (shrink)